Abstract: Large amount of water glass and oleic acid added to the tungsten ore mineral processing resulted in high concentration of water glass residual in the flotation wastewaterThus，the flotation wastewater was gelatinous and it was difficult for the suspended substance to settleResearches at home and abroad about flotation wastewater treatment are focused on the removal of organic mineral process reagent and heavy metalIn the practical mineral flotation wastewater treatment project，polyaluminium chloride（PAC） was generally used as coagulant to remove the suspended substance which was difficult to settleThis paper screened and combined the different coagulant and coagulant aid，meanwhile optimized the experimental parameters to improve the effluent quality and meet the reusable water quality standard requirementsThe experimental results showed the prepared simulated flotation wastewater based on the investigation of actual flotation wasterwater quality had the characteristics as follows：pH was 1226，turbidity was 1 390 NTU，suspended substance was 2 780 mg/L，Zeta potential was -59.9 mV. Calcium chloride（CaCl2） and 15 million molecular weight cationic polyacrylamide（PAM） were selected as the optimum coagulant and coagulant aid，the dosage was 500 mg/L and 30 mg/ L respectivelyUnder the experimental conditions of 450 r/min rapid stirring for 5 min，160 r/min slow stirring for 2 min，followed by settlement for 20 min，the turbidity of the supernatant was 7.11 NTU and the removal rate could reach 99.48%