Abstract: The coal power industry, while promoting the national economic and social development of China, also causes environmental pollution, thus threatening the health of employees and nearby residents.In order to evaluate the impact of occupational health damage factors in the life cycle of coal-fired power generation, an occupational health damage assessment system for coal-fired power generation is constructed based on LCA theory.Firstly, according to the actual situation of coal-fired power industry, this paper divides the life cycle of coal-fired power generation into different stages, then identifies the occupational health damage factors existing in each stage and carries out the process inventory analysis.Finally, through the characteristic and monetization analysis, a quantitative evaluation of occupational health damage in the life cycle of coal-fired power generation is achieved.The empirical analysis shows that among all the occupational health damage factors in the life cycle of coal-fired power generation and SO₂ causes the most serious health damage to human body.The evaluation results can provide a basis for health management and decision-making in coal-fired power industry.